Jump to main content
Jump to site search

Issue 9, 2005
Previous Article Next Article

Design and sterospecific synthesis of modular ligands based upon cis-1,3-trans-5-substituted cyclohexanes

Author affiliations

Abstract

A range of eight novel ligands, based on the cis-1,3-trans-5-substituted cyclohexane framework, have been synthesized by a stereospecific route starting from cis-1,3,5-cyclohexanetriol. This route depends on the use of efficient mono-silylation and mono-tosylation procedures, is well optimised, and due to isolation of the diazido alcohol precursor cis-3,5-diazido-trans-hydroxycyclohexane readily allows the synthesis of a sizeable family of related ligands via O-derivatisation. Such derivatisations allow systematic changes between various coordinating, hydrogen bonding and lipophilic groups, allowing potential for this ligand system to be utilised in supramolecular coordination chemistry.

Graphical abstract: Design and sterospecific synthesis of modular ligands based upon cis-1,3-trans-5-substituted cyclohexanes

Back to tab navigation
Please wait while Download options loads

Publication details

The article was received on 10 Mar 2005, accepted on 13 Jun 2005 and first published on 08 Jul 2005


Article type: Paper
DOI: 10.1039/B503606B
Citation: New J. Chem., 2005,29, 1152-1158
  •   Request permissions

    Design and sterospecific synthesis of modular ligands based upon cis-1,3-trans-5-substituted cyclohexanes

    J. Fielden, J. Sprott and L. Cronin, New J. Chem., 2005, 29, 1152
    DOI: 10.1039/B503606B

Search articles by author