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Issue 4, 2005
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Efficient solid-state NMR methods for measuring heteronuclear dipolar couplings in unoriented lipid membrane systems

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Abstract

Recently (Dvinskikh et al., J. Magn. Reson., 2003, 164, 165 and Dvinskikh et al., J. Magn. Reson., 2004, 168, 194), some of us introduced two efficient solid-state NMR techniques for the determination of heteronuclear dipolar couplings under magic-angle spinning (MAS). These two-dimensional (2D) recoupling methods have been applied previously to simple amino acids, and to columnar systems with high positional and orientational order. In this work, we show that the 2D MAS sequences produce unparalleled 1H–13C dipolar resolution in unoriented lipid membranes. The recoupling experiments were applied to hydrated dimyristoylphosphatidylcholine (DMPC) in the liquid-crystalline Lα phase, and the results agreed well with previous NMR investigations using specifically deuterated phospholipids.

Graphical abstract: Efficient solid-state NMR methods for measuring heteronuclear dipolar couplings in unoriented lipid membrane systems

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Publication details

The article was received on 01 Dec 2004, accepted on 12 Jan 2005 and first published on 24 Jan 2005


Article type: Paper
DOI: 10.1039/B418131J
Citation: Phys. Chem. Chem. Phys., 2005,7, 607-613
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    Efficient solid-state NMR methods for measuring heteronuclear dipolar couplings in unoriented lipid membrane systems

    S. V. Dvinskikh, V. Castro and D. Sandström, Phys. Chem. Chem. Phys., 2005, 7, 607
    DOI: 10.1039/B418131J

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