Issue 20, 2005
From the journal:

Chemical Communications

Aryl–aryl coupling via directed lithiation and oxidation†

David S. Surry,a   David J. Fox,a   Simon J. F. Macdonaldb  and  David R. Spring*a  

* Corresponding authors

a Department of Chemistry, University of Cambridge, Lensfield Road, Cambridge, UK
E-mail: drspring@ch.cam.ac.uk
Fax: +44 (0) 1223 336362
Tel: +44 (0) 1223 336498

b GlaxoSmithKline, Centre for Excellence in Drug Discovery, Stevenage, UK

Abstract

Aryl lithium reagents formed by directed lithiation reactions undergo transmetallation with copper(I) salts to form organocuprates, which may be efficiently oxidized to yield ortho-substituted biaryls.

Graphical abstract: Aryl–aryl coupling via directed lithiation and oxidation

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Article information

DOI
https://doi.org/10.1039/B501939G
Article type
Communication
Submitted
09 Feb 2005
Accepted
01 Apr 2005
First published
12 Apr 2005

Chem. Commun., 2005, 2589-2590

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Aryl–aryl coupling via directed lithiation and oxidation

D. S. Surry, D. J. Fox, S. J. F. Macdonald and D. R. Spring, Chem. Commun., 2005, 2589 DOI: 10.1039/B501939G

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