Issue 16, 2005
From the journal:

Chemical Communications

Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection†

Jonathan K. Pokorski,a   Jwa-Min Nam,b   Rafael A. Vega,b   Chad A. Mirkinb  and  Daniel H. Appella*a  

* Corresponding authors

a Northwestern University and NIH, NIDDK, Laboratory of Bioorganic Chemistry, Bethesda, MD, USA
E-mail: appellad@niddk.nih.gov

b Northwestern University, Department of Chemistry and Institute for Nanotechnology, 2145 Sheridan Rd, Evanston, IL, USA
E-mail: chadnano@northwestern.edu

Abstract

trans-Cyclopentane-modified PNA has been successfully utilized as a target capture strand to improve the detection limit of a known DNA detection assay, and provide high levels of mismatch discrimination.

Graphical abstract: Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection

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Article information

DOI
https://doi.org/10.1039/B418383E
Article type
Communication
Submitted
06 Dec 2004
Accepted
11 Feb 2005
First published
09 Mar 2005

Chem. Commun., 2005, 2101-2103

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Cyclopentane-modified PNA improves the sensitivity of nanoparticle-based scanometric DNA detection

J. K. Pokorski, J. Nam, R. A. Vega, C. A. Mirkin and D. H. Appella, Chem. Commun., 2005, 2101 DOI: 10.1039/B418383E

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