Issue 18, 2004
From the journal:

Organic & Biomolecular Chemistry

The synthesis of unsymmetrically N-substituted chiral 1,4,7-triazacyclononanes†

J. Erik W. Scheuermann,a   Kevin F. Sibbons,a   David M. Benoit,ab   Majid Motevallia  and  Michael Watkinson*a  

* Corresponding authors

a Department of Chemistry, Queen Mary, University of London, Mile End Road, London, UK
E-mail: m.watkinson@qmul.ac.uk
Fax: +44 (0)20 7882 7427
Tel: +44 (0)20 7882 3263

b Department of Chemistry, University College London, Christopher Ingold Laboratories, 20 Gower Street, London, UK

Abstract

A number of chiral unsymmetrically N-substituted 1,4,7-triazacyclononane ligands have been prepared by modular methods. The key step in the synthesis centres on the macrocyclisation of three tertiary amide precursors under standard Richman–Atkins conditions which allows for subsequent N-functionalisation.

Graphical abstract: The synthesis of unsymmetrically N-substituted chiral 1,4,7-triazacyclononanes

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Article information

DOI
https://doi.org/10.1039/B409259G
Article type
Paper
Submitted
18 Jun 2004
Accepted
23 Jul 2004
First published
24 Aug 2004

Org. Biomol. Chem., 2004,2, 2664-2670

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The synthesis of unsymmetrically N-substituted chiral 1,4,7-triazacyclononanes

J. E. W. Scheuermann, K. F. Sibbons, D. M. Benoit, M. Motevalli and M. Watkinson, Org. Biomol. Chem., 2004, 2, 2664 DOI: 10.1039/B409259G

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