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Issue 14, 2004
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RNAi: running interference for the cell

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Abstract

RNA interference or RNAi is a recently characterized mechanism of eukaryotic gene regulation in which a short sequence of double-stranded RNA (dsRNA) specifically down-regulates expression of the associated gene. Preliminary characterization of this phenomenon has revealed a set of inter-related cellular pathways which appear to represent both a response to foreign RNA and a mechanism of endogenous gene regulation. Introduction of dsRNA into cells by a variety of means, including transfection of synthetic RNA duplexes, triggers the RNAi response resulting in specific suppression of target gene expression. Recent efforts on a genome wide scale have involved application of RNAi as an important new tool in cell biology to elucidate gene function in living cells.

Graphical abstract: RNAi: running interference for the cell

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Publication details

The article was received on 01 Apr 2004 and first published on 28 Jun 2004


Article type: Perspective
DOI: 10.1039/B404932M
Citation: Org. Biomol. Chem., 2004,2, 1957-1961
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    RNAi: running interference for the cell

    O. A. Kent and A. M. MacMillan, Org. Biomol. Chem., 2004, 2, 1957
    DOI: 10.1039/B404932M

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