Issue 15, 2004
From the journal:

Chemical Communications

Lipase catalysed Michael addition of secondary amines to acrylonitrile

Oliver Torre,a   Ignacio Alfonsoa  and  Vicente Gotor*a  

* Corresponding authors

a Departamento de Química Orgánica e Inorgánica, Universidad de Oviedo, C/Julián Clavería, 8, E-33071 Oviedo, Spain
E-mail: vgs@sauron.quimica.uniovi.es
Fax: +34 985103448
Tel: +34 985103448

Abstract

A new enzymatic process is described. Different preparations of lipase B from Candida antarctica are able to catalyse Michael-type addition of secondary amines to acrylonitrile. This new reaction widens the applicability of these biocatalysts in organic synthesis.

Graphical abstract: Lipase catalysed Michael addition of secondary amines to acrylonitrile

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Article information

DOI
https://doi.org/10.1039/B402244K
Article type
Communication
Submitted
13 Feb 2004
Accepted
11 Jun 2004
First published
28 Jun 2004

Chem. Commun., 2004, 1724-1725

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Lipase catalysed Michael addition of secondary amines to acrylonitrile

O. Torre, I. Alfonso and V. Gotor, Chem. Commun., 2004, 1724 DOI: 10.1039/B402244K

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