Issue 16, 2003
From the journal:

Organic & Biomolecular Chemistry

Cation transport by a redox-active synthetic ion channel

Adam C. Hall,*a   Cristina Suarez,b   Anindita Hom-Choudhury,b   Aida N. A. Manu,a   C. Dennis Hall,c   Gregory J. Kirkovitsc  and  Ion Ghirivigad  

* Corresponding authors

a Department of Biological Sciences, Smith College, MA 01063, USA
E-mail: ahall@smith.edu

b Department of Chemistry, Smith College, MA 01063, USA

c Department of Chemistry, King's College, London, UK

d Department of Chemistry, University of Florida, Gainesville, FL 32611, USA

Abstract

The synthesis, cation binding and transmembrane conductive properties of a novel group of synthetic ion channels containing a redox-active centre are described. Experiments using a black lipid membrane preparation revealed that these compounds function effectively as ion channels. Subsequent 23Na NMR spectroscopy studies focused on a synthesized ion channel with a ferrocene centre. When incorporated in vesicular bilayers, this channel was demonstrated to support a Na+ flux that was at least six times faster than ion transport by monensin. Since oxidation of the ferrocene moiety completely inhibited the Na+ transport, the redox-active centre provides a potential mechanism for controlling ion flux.

Graphical abstract: Cation transport by a redox-active synthetic ion channel

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Article information

DOI
https://doi.org/10.1039/B304838A
Article type
Paper
Submitted
02 May 2003
Accepted
23 Jun 2003
First published
10 Jul 2003

Org. Biomol. Chem., 2003,1, 2973-2982

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Cation transport by a redox-active synthetic ion channel

A. C. Hall, C. Suarez, A. Hom-Choudhury, A. N. A. Manu, C. D. Hall, G. J. Kirkovits and I. Ghiriviga, Org. Biomol. Chem., 2003, 1, 2973 DOI: 10.1039/B304838A

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