Issue 10, 2003
From the journal:

Organic & Biomolecular Chemistry

Traceless solid phase synthesis of 2-substituted pyrimidines using an ‘off-the-shelf’ chlorogermane-functionalised resin†

Alan C. Spivey,*ab   Ratnasothy Srikaran,a   Christopher M. Diapera  and  David J. Turnera  

* Corresponding authors

a Department of Chemistry, University of Sheffield, Brook Hill, Sheffield, Yorkshire, UK

b Department of Chemistry, Imperial College London, South Kensington campus, London, UK
E-mail: a.c.spivey@imperial.ac.uk
Fax: +44 (0)20 75945833
Tel: +44 (0)20 75945841

Abstract

The parallel solid phase synthesis of an 18-member library of 2-substituted pyrimidines is described using a chlorogermane-functionalised resin. The success of the key Pinner-type condensations between a resin-bound enaminone and an array of amidine hydrochlorides highlights the stability of arylgermane linkers (cf. arylsilanes) towards strongly basic/nucleophilic conditions.

Graphical abstract: Traceless solid phase synthesis of 2-substituted pyrimidines using an ‘off-the-shelf’ chlorogermane-functionalised resin

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Article information

DOI
https://doi.org/10.1039/B303064D
Article type
Communication
Submitted
20 Mar 2003
Accepted
16 Apr 2003
First published
25 Apr 2003

Org. Biomol. Chem., 2003,1, 1638-1640

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Traceless solid phase synthesis of 2-substituted pyrimidines using an ‘off-the-shelf’ chlorogermane-functionalised resin

A. C. Spivey, R. Srikaran, C. M. Diaper and D. J. Turner, Org. Biomol. Chem., 2003, 1, 1638 DOI: 10.1039/B303064D

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