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Issue 11, 2003
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Optically pure β-substituted β-hydroxy aspartates as glutamate transporter blockers

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Abstract

A short asymmetric synthesis of optically pure β-substituted β-hydroxy aspartates is described. The key step is an aldol reaction between a glycine enolate derived from an oxazinone intermediate used as chiral auxiliary and various α-keto esters. Excellent diastereomeric excesses are obtained.

Graphical abstract: Optically pure β-substituted β-hydroxy aspartates as glutamate transporter blockers

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Publication details

The article was received on 20 Dec 2002, accepted on 26 Mar 2003 and first published on 07 May 2003


Article type: Paper
DOI: 10.1039/B212538B
Citation: Org. Biomol. Chem., 2003,1, 1938-1942
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    Optically pure β-substituted β-hydroxy aspartates as glutamate transporter blockers

    J. Wehbe, T. Kassem, V. Rolland, M. Rolland, M. Tabcheh, M. Roumestant and J. Martinez, Org. Biomol. Chem., 2003, 1, 1938
    DOI: 10.1039/B212538B

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