Issue 3, 2003
From the journal:

New Journal of Chemistry

Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

Janine Cossy,*a   Olivier Mirguet,a   Domingo Gomez Pardoa  and  Jean-Roger Desmursb  

* Corresponding authors

a Laboratoire de Chimie Organique, ESPCI, 10 rue Vauquelin, Paris Cedex 05, France
E-mail: janine.cossy@espci.fr
Fax: +33 (0)1 4079 4660
Tel: +33 (0)1 4079 4429

b Rhodia, 190 avenue Thiers, Lyon Cedex 06, France

Abstract

The diastereoselective conjugate addition of an organocopper reagent to a chiral racemic olefinic amido ester has been used as the key step in a formal total synthesis of paroxetine.

Graphical abstract: Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

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Article information

DOI
https://doi.org/10.1039/B209181J
Article type
Paper
Submitted
16 Sep 2002
Accepted
12 Nov 2002
First published
28 Jan 2003

New J. Chem., 2003,27, 475-482

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Diastereoselective conjugate addition of organocuprates to chiral racemic olefinic amido esters. Formal total synthesis of paroxetine

J. Cossy, O. Mirguet, D. G. Pardo and J. Desmurs, New J. Chem., 2003, 27, 475 DOI: 10.1039/B209181J

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