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Issue 19, 2003
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Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate

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Abstract

Comparison of the kinetic and parallel kinetic resolutions of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate allows for the efficient synthesis of both (1R,2S,5S)- and (1S,2R,5R)-enantiomers of methyl 2-amino-5-tert-butyl-cyclopentane-1-carboxylate.

Graphical abstract: Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate

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Publication details

The article was received on 29 Jul 2003, accepted on 14 Aug 2003 and first published on 26 Aug 2003


Article type: Communication
DOI: 10.1039/B308855C
Citation: Chem. Commun., 2003,0, 2410-2411
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    Preparation of methyl (1R,2S,5S)- and (1S,2R,5R)-2-amino-5-tert-butyl-cyclopentane-1-carboxylates by parallel kinetic resolution of methyl (RS)-5-tert-butyl-cyclopentene-1-carboxylate

    S. G. Davies, D. Díez, M. M. El Hammouni, A. Christopher Garner, N. M. Garrido, M. J. C. Long, R. M. Morrison, A. D. Smith, M. J. Sweet and J. M. Withey, Chem. Commun., 2003, 0, 2410
    DOI: 10.1039/B308855C

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