Issue 10, 2003
From the journal:

Chemical Communications

Biarylpyrimidines: a new class of ligand for high-order DNA recognition†

Peter M. Murphy,a   Victoria A. Phillips,a   Sharon A. Jennings,ab   Nichola C. Garbett,c   Jonathan B. Chaires,c   Terence C. Jenkinsb  and  Richard T. Wheelhouse*a  

* Corresponding authors

a School of Pharmacy, University of Bradford, Bradford, West Yorkshire, UK
E-mail: r.t.wheelhouse@bradford.ac.uk
Fax: 44 1274 235600
Tel: 44 1274 234710

b Yorkshire Cancer Research Laboratory of Drug Design, Tom Connors Cancer Research Centre, University of Bradford, Bradford, West Yorkshire, UK

c Department of Biochemistry, University of Mississippi Medical Center, 2500 North State Street, Jackson, Mississippi, 39216-4505, USA

Abstract

Biarylpyrimidines bearing ω-aminoalkyl substituents have been designed as ligands for high-order DNA structures: spectrophotometric, thermal and competition equilibrium dialysis assays showed that changing the functional group for substituent attachment from thioether to amide switches the structural binding preference from triplex to tetraplex DNA; the novel ligands are non-toxic and moderate inhibitors of human telomerase.

Graphical abstract: Biarylpyrimidines: a new class of ligand for high-order DNA recognition

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Article information

DOI
https://doi.org/10.1039/B301554H
Article type
Communication
Submitted
12 Feb 2003
Accepted
05 Mar 2003
First published
09 Apr 2003

Chem. Commun., 2003, 1160-1161

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Biarylpyrimidines: a new class of ligand for high-order DNA recognition

P. M. Murphy, V. A. Phillips, S. A. Jennings, N. C. Garbett, J. B. Chaires, T. C. Jenkins and R. T. Wheelhouse, Chem. Commun., 2003, 1160 DOI: 10.1039/B301554H

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