Issue 8, 2003
From the journal:

Chemical Communications

Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols

Dongliang Chang,a   Zunsheng Wang,a   Maarten F. Heringa,a   Renato Wirthner,a   Bernard Witholta  and  Zhi Li*a  

* Corresponding authors

a Institute of Biotechnology, Swiss Federal Institute of Technology Zurich, ETH-Hoenggerberg, CH-8093 Zurich, Switzerland
E-mail: zhi@biotech.biol.ethz.ch
Fax: +41 1 633 1051
Tel: +41 1 633 3811

Abstract

Hydrolysis of N-benzyloxycarbonyl-3,4-epoxy-pyrrolidine and cyclohexene oxide with the epoxide hydrolase of Sphingomonas sp. HXN-200, respectively, gave the corresponding vicinal trans-diols in high ee and yield, representing the first example of enantioselective hydrolysis of a meso-epoxide with a bacterial epoxide hydrolase.

Graphical abstract: Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols

About
Cited by
Related
Download options Please wait...

Article information

DOI
https://doi.org/10.1039/B300435J
Article type
Communication
Submitted
14 Jan 2003
Accepted
05 Mar 2003
First published
18 Mar 2003

Chem. Commun., 2003, 960-961

Permissions

Request permissions

Highly enantioselective hydrolysis of alicyclic meso-epoxides with a bacterial epoxide hydrolase from Sphingomonas sp. HXN-200: simple syntheses of alicyclic vicinal trans-diols

D. Chang, Z. Wang, M. F. Heringa, R. Wirthner, B. Witholt and Z. Li, Chem. Commun., 2003, 960 DOI: 10.1039/B300435J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements