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Issue 4, 2003
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A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids

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Abstract

A new chiral glycine equivalent 7 has been synthesised from glycidol using a chiral memory protocol, and its use in the synthesis of N-Z protected α-amino acids was demonstrated in a series of diasteroselective lithium enolate alkylation reactions and subsequent acid hydrolyses.

Graphical abstract: A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids

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Publication details

The article was received on 30 Oct 2002, accepted on 22 Nov 2002 and first published on 20 Jan 2003


Article type: Communication
DOI: 10.1039/B210673F
Citation: Chem. Commun., 2003,0, 468-469
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    A 2,3-butanedione protected chiral glycine equivalent—a new building block for the stereoselective synthesis of enantiopure N-protected α-amino acids

    D. J. Dixon, C. I. Harding, S. V. Ley and D. M. G. Tilbrook, Chem. Commun., 2003, 0, 468
    DOI: 10.1039/B210673F

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