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Issue 12, 2002
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Synthesis and evaluation of colorimetric chemosensors for monitoring sodium and potassium ions in the intracellular concentration range

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Abstract

The azo-dye based colorimetric chemosensors 1 and 2 were designed for the detection of intracellular concentrations of Na+ and K+ respectively. The two sensors were synthesised from the o-anisidine based receptors 3 and 4 in a one step synthesis. Both displayed good selectivity and sensitivity for the relevant group I cations in the appropriate physiological conditions, with 1 displaying large changes in the absorption spectra upon Na+ recognition with λmax being shifted from 488 nm to 377 nm in the absorption spectra when measured in 50 ∶ 50 MeOHH2O buffered pH 7.4 solutions and in the presence of high ionic strength. Similarly, 2 showed both a hypsochromic shift and hypochromic effect upon titration with K+. These changes were clearly visible; with red to yellow colour changes taking place upon ion recognition.

Graphical abstract: Synthesis and evaluation of colorimetric chemosensors for monitoring sodium and potassium ions in the intracellular concentration range

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Publication details

The article was received on 01 Aug 2002, accepted on 17 Sep 2002 and first published on 17 Oct 2002


Article type: Paper
DOI: 10.1039/B207551M
Citation: J. Chem. Soc., Perkin Trans. 2, 2002,0, 1980-1985
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    Synthesis and evaluation of colorimetric chemosensors for monitoring sodium and potassium ions in the intracellular concentration range

    T. Gunnlaugsson and J. P. Leonard, J. Chem. Soc., Perkin Trans. 2, 2002, 0, 1980
    DOI: 10.1039/B207551M

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