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Issue 22, 2001
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Asymmetric synthesis of β-amino acid scaffolds

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Abstract

Addition of two or three equivalents of lithium (S)-N-benzyl-N-α-methylbenzylamide to conjugate acceptors containing two or three α,β-unsaturated ester fragments respectively and subsequent hydrogenolytic deprotection afford homochiral bis- or tris-β-amino esters containing two or three new stereogenic centres in high de and ee.

Graphical abstract: Asymmetric synthesis of β-amino acid scaffolds

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Publication details

The article was received on 16 Aug 2001, accepted on 02 Oct 2001 and first published on 29 Oct 2001


Article type: Paper
DOI: 10.1039/B107440G
Citation: J. Chem. Soc., Perkin Trans. 1, 2001,0, 2931-2938
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    Asymmetric synthesis of β-amino acid scaffolds

    S. D. Bull, S. G. Davies and A. D. Smith, J. Chem. Soc., Perkin Trans. 1, 2001, 0, 2931
    DOI: 10.1039/B107440G

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