Issue 22, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Asymmetric synthesis of β-amino acid scaffolds

Steven D. Bull,a   Stephen G. Davies*a  and  Andrew D. Smitha  

* Corresponding authors

a The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK

Abstract

Addition of two or three equivalents of lithium (S)-N-benzyl-N-α-methylbenzylamide to conjugate acceptors containing two or three α,β-unsaturated ester fragments respectively and subsequent hydrogenolytic deprotection afford homochiral bis- or tris-β-amino esters containing two or three new stereogenic centres in high de and ee.

Graphical abstract: Asymmetric synthesis of β-amino acid scaffolds

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Article information

DOI
https://doi.org/10.1039/B107440G
Article type
Paper
Submitted
16 Aug 2001
Accepted
02 Oct 2001
First published
29 Oct 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 2931-2938

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Asymmetric synthesis of β-amino acid scaffolds

S. D. Bull, S. G. Davies and A. D. Smith, J. Chem. Soc., Perkin Trans. 1, 2001, 2931 DOI: 10.1039/B107440G

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