Issue 12, 2001
From the journal:

Journal of the Chemical Society, Perkin Transactions 1

Palladium catalysed elaboration of codeine and morphine

Stephen G. Davies,*a   Christopher J. Goodwin,b   Dirk Pyatta  and  Andrew D. Smitha  

* Corresponding authors

a The Dyson Perrins Laboratory, University of Oxford, South Parks Road, Oxford, UK

b AstraZeneca R & D Charnwood, Bakewell Road, Loughborough, Leicestershire, UK

Abstract

Palladium catalysed coupling reactions of 6-O-tert-butyldimethylsilyl-1-bromocodeine and 6-O-tert-butyldimethylsilyl-3-trifluoromethylsulfonylmorphine allow a range of substituted analogues of codeine in the 1-position and morphine in the 3-position to be efficiently and selectively prepared.

Graphical abstract: Palladium catalysed elaboration of codeine and morphine

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Article information

DOI
https://doi.org/10.1039/B102581N
Article type
Paper
Submitted
20 Mar 2001
Accepted
03 May 2001
First published
22 May 2001

J. Chem. Soc., Perkin Trans. 1, 2001, 1413-1420

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Palladium catalysed elaboration of codeine and morphine

S. G. Davies, C. J. Goodwin, D. Pyatt and A. D. Smith, J. Chem. Soc., Perkin Trans. 1, 2001, 1413 DOI: 10.1039/B102581N

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