Uncatalysed reactions in water: Part 2.Part 1: ref. 1. Preparation of 3-carboxycoumarins
Abstract
A simple, efficient and environmentally friendly procedure has been developed for the reaction of Meldrum’s acid with salicylaldehydes. 3-Carboxycoumarins 5 were synthesised in high yields (78–96%) and excellent selectivities (95–98%) by carrying out the reaction in water at reflux for 10 h, avoiding the addition of any catalyst.