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Issue 24, 2001
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Pseudoxazolones, a new class of inhibitors for cysteine proteinases: inhibition of hepatitis A virus and human rhinovirus 3C proteinases

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Abstract

Monophenyl and diphenyl pseudoxazolone derivatives of glycine and alanine were prepared and found to be time-dependent inhibitors of hepatitis A virus (HAV) 3C and human rhinovirus (HRV) 3C proteinases with IC50 values in the micromolar range.

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Publication details

The article was received on 09 Oct 2001, accepted on 14 Nov 2001 and first published on 06 Dec 2001


Article type: Communication
DOI: 10.1039/B109095J
Citation: Chem. Commun., 2001,0, 2740-2741
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    Pseudoxazolones, a new class of inhibitors for cysteine proteinases: inhibition of hepatitis A virus and human rhinovirus 3C proteinases

    Y. K. Ramtohul, N. I. Martin, L. Silkin, M. N. G. James and J. C. Vederas, Chem. Commun., 2001, 0, 2740
    DOI: 10.1039/B109095J

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