Reactive immunization elicits catalytic antibodies for polyester hydrolysis

Da-Wei Chen; Robert J. Kubiak; Jon A. Ashley; Kim D. Janda

doi:10.1039/B105412K

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Journal of the Chemical Society, Perkin Transactions 1

Issue 21, 2001

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Reactive immunization elicits catalytic antibodies for polyester hydrolysis

Da-Wei Chen , Robert J. Kubiak , Jon A. Ashley and Kim D. Janda

J. Chem. Soc., Perkin Trans. 1, 2001, 2796-2803

DOI: 10.1039/B105412K
Received 20 Jun 2001, Accepted 20 Aug 2001
First published on the web 09 Oct 2001

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Abstract
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In the search for biocatalysts for degradation of nonnatural polymers, reactive immunization with haptens 7 and 11 was used to prepare catalytic antibodies capable of cleaving short oligomeric esters, as well as the insoluble polyester 25. These antibodies were found to be highly specific and efficient esterases for oligomers. Triester 24 was preferentially hydrolyzed by an endo-cleavage pathway, however, with a higher molecular weight polymer 25 no site specificity could be observed. Catalytic efficiency of the antibodies towards the insoluble polymer 25 was limited due to physical constraints.

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Journal of the Chemical Society, Perkin Transactions 1

Reactive immunization elicits catalytic antibodies for polyester hydrolysis

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