Synthesis, cytotoxicity and DNA cross-linking activityof symmetrical dimers based upon the epoxide domain of the azinomycins

John A. Hartley; Ali Hazrati; Timothy J. Hodgkinson; Lloyd R. Kelland; Ruzwana Khanim; Michael Shipman; Franck Suzenet

doi:10.1039/B006723G

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Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the

John A. Hartley,^a Ali Hazrati,^a Timothy J. Hodgkinson,^b Lloyd R. Kelland,^c Ruzwana Khanim,^a Michael Shipman*^b and Franck Suzenet^b

Author affiliations

* Corresponding authors

^a CRC Drug-DNA Interactions Research Group, Department of Oncology, Royal Free & University College Medical School, University College London, 91 Riding House Street, London, UK

^b School of Chemistry, University of Exeter, Stocker Road, Exeter, UK
E-mail: m.shipman@exeter.ac.uk;
Fax: +44-1392-263434
Tel: +44-1392-263469

^c CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK

Abstract

A series of dimeric compounds 1a–c designed around the epoxide domain of the azinomycins have been synthesised and demonstrated to be highly efficient DNA interstrand cross-linking agents.

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Article information

DOI: https://doi.org/10.1039/B006723G
Article type: Communication
Submitted: 15 Aug 2000
Accepted: 13 Oct 2000
First published: 09 Nov 2000

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Chem. Commun., 2000, 2325-2326

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Synthesis, cytotoxicity and DNA cross-linking activity of symmetrical dimers based upon the epoxide domain of the azinomycins

J. A. Hartley, A. Hazrati, T. J. Hodgkinson, L. R. Kelland, R. Khanim, M. Shipman and F. Suzenet, Chem. Commun., 2000, 2325 DOI: 10.1039/B006723G

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Chemical Communications