Issue 18, 2000
From the journal:

Chemical Communications

Generation of metalloenamines by carbon–carbon bond formation: ring opening reactions of 2-methyleneaziridines with organometallic reagents

Jerome F. Hayes,a   Michael Shipman*b  and  Heather Twinb  

* Corresponding authors

a SmithKline Beecham Pharmaceuticals, Old Powder Mills, Tonbridge, Kent, UK

b School of Chemistry, University of Exeter, Exeter, Devon, UK
E-mail: M.Shipman@exeter.ac.uk

Abstract

Ring opening of 2-methyleneaziridines with Grignard reagents in the presence of CuI yields metalloenamines in a regiospecific fashion which can be further reacted with electrophiles to produce functionalised ketones via a one-pot process.

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Article information

DOI
https://doi.org/10.1039/B005623P
Article type
Communication
Submitted
07 Jul 2000
Accepted
31 Jul 2000
First published
04 Sep 2000

Chem. Commun., 2000, 1791-1792

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Generation of metalloenamines by carbon–carbon bond formation: ring opening reactions of 2-methyleneaziridines with organometallic reagents

J. F. Hayes, M. Shipman and H. Twin, Chem. Commun., 2000, 1791 DOI: 10.1039/B005623P

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