Efficient One Step Transformation of Carboxylic Acids to Nitriles with the Carbon Chain Shortened by One Carbon Atom

Abstract

Nitrozation of ω-substituted alkanoic acids of the general formula X(CH₂)_nCO₂H (X=Cl, CO₂H, CO₂Me, PhthN), bulky substituted alkanoic acids, arylacetic acids containing electron withdrawing substituents in the aromatic ring, o-tosylhydroxyphenylacetic acids and N-phtaloilaminophenylacetic acids yield nitriles with the carbon chain shortened by one (or two for dicarboxylic acids) carbon atom.