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Issue 10, 1999
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Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

Abstract

A human cancer cell line bioassay-directed investigation of the Western Pacific marine sponge Agelas sp. led to isolation of a trace (7.42 × 10–6% yield) cancer cell growth inhibitor (lung NCI-H460 GI50 0.77 µg m–1 to ovary OVCAR-3 GI50 2.8 µg ml–1) designated agelagalastatin 6; it is the first example of a natural product containing a digalactofuranosyl unit.

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Article type: Paper
DOI: 10.1039/A902380A
Citation: Chem. Commun., 1999, 915-916
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    Antineoplastic agents. Part 395.1 Isolation and structure of agelagalastatin from the Papua New Guinea marine sponge Agelas sp.

    G. R. Pettit, J. Xu, D. E. Gingrich, M. D. Williams, D. L. Doubek, J. Chapuis and J. M. Schmidt, Chem. Commun., 1999, 915
    DOI: 10.1039/A902380A

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