A new and enantioselective indolizidine synthesis by meso-epoxide α-deprotonation–transannular N–C insertion
Abstract
Enantioselective α-deprotonation–rearrangement of N-Boc hexahydroazonine oxide 10 using organolithiums in the presence of (-)-sparteine 3 gives the ester 12 in up to 89% ee.