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Issue 21, 1996
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Sequential biocatalytic resolution of (±)-trans-cyclohexane-1,2-diamine. Chemoenzymatic synthesis of an optically active polyamine

Abstract

Candida antarctica lipase-catalysed double monoaminolysis of dimethyl malonate by (±)-trans-cyclohexane-1,2-diamine allows the sequential resolution of the latter compound, affording an enantiopure bis(amidoester), (R,R)-3, which is subsequently transformed into an optically active polyamine, (R,R)-9.

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Article type: Paper
DOI: 10.1039/CC9960002471
Citation: Chem. Commun., 1996,0, 2471-2472
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    Sequential biocatalytic resolution of (±)-trans-cyclohexane-1,2-diamine. Chemoenzymatic synthesis of an optically active polyamine

    I. Alfonso, C. Astorga, F. Rebolledo and V. Gotor, Chem. Commun., 1996, 0, 2471
    DOI: 10.1039/CC9960002471

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