Issue 13, 1995

Cuprous bromide-promoted cyclization of ketene N,S-acetals with prop-2-ynyl bromide: synthesis of regiospecifically substituted and annelated 3-acyl(or nitro)-5-methyl pyrroles

Abstract

Acyclic 10ah and cyclic 14ab acyl and nitroketene 12abN,S-acetals undergo facile cuprous bromide induced cyclization with prop-2-ynyl bromide to afford 1-substituted-3-acyl(or nitro)-5-methyl-2-(methylsulfanyl)pyrroles 11ah and 13ab and the corresponding annelated analogues 15ab in good yields.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1995, 1725-1727

Cuprous bromide-promoted cyclization of ketene N,S-acetals with prop-2-ynyl bromide: synthesis of regiospecifically substituted and annelated 3-acyl(or nitro)-5-methyl pyrroles

A. K. Gupta, K. R. Reddy, H. Ila and H. Junjappa, J. Chem. Soc., Perkin Trans. 1, 1995, 1725 DOI: 10.1039/P19950001725

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