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Issue 13, 1995
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A new short and efficient strategy for the synthesis of quinolone antibiotics

Abstract

A simple protocol for the synthesis of quinolone antibiotics is exemplified for the synthesis of norfloxacin; 3-chloro-4-fluoroaniline with triethyl orthoformate is transformed into its N-ethyl-N-formyl derivative which reacts with methyl malonyl morpholide and phosphoryl chloride at 100 °C to give 6-fluoro-7-chloro-1-ethylquinol-4-one-3-carboxylic acid, which has previously been converted into norfloxacin by the action of piperazine.

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Article type: Paper
DOI: 10.1039/C39950001319
Citation: J. Chem. Soc., Chem. Commun., 1995,0, 1319-1319
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    A new short and efficient strategy for the synthesis of quinolone antibiotics

    A. Jackson and O. Meth-Cohn, J. Chem. Soc., Chem. Commun., 1995, 0, 1319
    DOI: 10.1039/C39950001319

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