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Issue 11, 1995
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Lithium (α-methylbenzyl)allylamide: a differentially protected chiral ammonia equivalent for the asymmetric synthesis of β-amino acids and β-lactams

Abstract

The addition products from the highly stereoselective conjugate additions of lithium (αS)-(α-methylbenzyl)allylamide to α, β-unsaturated tert-butyl esters are efficiently deallylated with tris(triphenylphosphine)rhodium(I) chloride and converted, after transesterification to the methyl esters and cyclisation with methylmagnesium bromide, to the corresponding homochiral N-(α-methylbenzyl)-4-substituted-azetidm-2-ones.

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Article type: Paper
DOI: 10.1039/C39950001109
Citation: J. Chem. Soc., Chem. Commun., 1995,0, 1109-1110
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    Lithium (α-methylbenzyl)allylamide: a differentially protected chiral ammonia equivalent for the asymmetric synthesis of β-amino acids and β-lactams

    S. G. Davies and D. R. Fenwick, J. Chem. Soc., Chem. Commun., 1995, 0, 1109
    DOI: 10.1039/C39950001109

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