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Issue 2, 1995
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Asymmetric synthesis of the enantiomers of the diarylcarbinol (1R)- and (1S)-1-(1-hydroxyphenylmethyl)-2-hydroxybenzene

Abstract

(1S)-1-Phenethyl(phenyl chromium tricarbonyl) ether (–)-4 undergoes completely stereoselective ortho-deprotonation with the thus formed carbanion being converted by the complementary sequences, benzoylation/hydride reduction and formylation/PhMgBr addition, to generate after decomplexation and deprotection the homochiral diarylcarbinols (–)-(1R)- and (+)-(1S)-1-(1-hydroxyphenylmethyl)-2-hydroxybenzene 1, respectively.

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Article type: Paper
DOI: 10.1039/C39950000251
Citation: J. Chem. Soc., Chem. Commun., 1995,0, 251-252
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    Asymmetric synthesis of the enantiomers of the diarylcarbinol (1R)- and (1S)-1-(1-hydroxyphenylmethyl)-2-hydroxybenzene

    S. G. Davies and W. E. Hume, J. Chem. Soc., Chem. Commun., 1995, 0, 251
    DOI: 10.1039/C39950000251

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