The enantioselective synthesis of an important intermediate to the antiviral, (–)-carbovir
Abstract
Two new routes to the important intermediate (–)-8 for the carbocyclic-based nucleosides are reported. The intermediate (–)-8 has also been synthesised in high. Enantiomeric excess via an enzymatic resolution of the racemic amide (+)-8 or an enzymatic enantiotopic hydrolysis of the meso diester 12.