Issue 21, 1993

Synthesis of the naturally occurring indolequinone BE 10988, an inhibitor of topoisomerase II

Abstract

A short synthesis (28% overall yield) of the naturally occurring indolequinone BE 10988 1 is described. The synthesis starts from 4-benzyloxy-5-methoxyindole and involves, as key steps, the use of chlorosulfonyl isocyanate to introduce the amide side-chain into the indole 3-position, followed by thioamide formation and construction of the thiazole ring using a Hantzsch reaction.

Article information

Article type
Paper

J. Chem. Soc., Perkin Trans. 1, 1993, 2561-2565

Synthesis of the naturally occurring indolequinone BE 10988, an inhibitor of topoisomerase II

C. J. Moody and E. Swann, J. Chem. Soc., Perkin Trans. 1, 1993, 2561 DOI: 10.1039/P19930002561

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