Michael reaction of functionalized chiral cyclanone imines. Enantioselective synthesis of C2-symmetric cis-(1R,6R)-1,6-dimethylbicyclo[4.4.0]decane-3,8-dione
Abstract
Enantioselective Michael reaction of methyl acrylate or methyl vinyl ketone with a chiral imine of 2-methylcyclohexanone having a protected carbonyl function in the 4-position 2 led to monoprotected keto ester 4 or dione 6. The latter was converted into the title compound 10.