Issue 2, 1993

Modelling radical-initiated DNA cleavage by vinyl epoxides

Abstract

Allyloxy radicals, formed by addition of thio radicals to vinyl epoxides, are shown to abstract hydrogen atoms and to add to alkene π-bonds in reactions which model the chemistry that would be required to induce DNA damaqe this suggests that vinyl epoxides could have uses as radiosensitizers for treatment of resistant tumours.

Article information

Article type
Paper

J. Chem. Soc., Chem. Commun., 1993, 191-192

Modelling radical-initiated DNA cleavage by vinyl epoxides

A. P. Breen and J. A. Murphy, J. Chem. Soc., Chem. Commun., 1993, 191 DOI: 10.1039/C39930000191

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