Synthesis of isotopically labelled 3-amino-2-phenylpropionic acid and its role as a precursor in the biosynthesis of tenellin and tropic acid
Abstract
A synthesis of [3-13C]- and [3-14C]-3-amino-2-phenylpropionic acids 7a and 7b is described. The incorporation of this amino acid into tenellin 1 from Beauveria bassiana(Bals.) Vuill. and into tropic acid 10 moiety of the tropane alkaloids hyscoyamine 8 and scopolamine 9 from Datura innoxia was studied but proved unsuccessful in each case.