Ring syntheses of the four N-methylprotoporphyrin isomers and of related N-methyl and N,N′-dimethylporphyrins
Abstract
Total syntheses of the four isomeric N-methylprotoporphyrin IX dimethyl esters have been achieved by the MacDonald and tripyrrene/a,c-biladiene routes using appropriate N-methylpyrroles and N-methyldipyrromethanes as intermediates. The syntheses of related N-methyl and N,N′-dimethylporphyrins have also been achieved by the MacDonald route.