Issue 2, 1991

Flow injection method for the assay of phenothiazine neuroleptics in pharmaceutical preparations using ammonium metavanadate

Abstract

A simple flow injection method for the determination of chlorpromazine, promethazine, trimeprazine and perphenazine over wide ranges of concentrations is described. The method is based on the oxidation of phenothiazine with ammonium metavanadate in sulphuric acid media and subsequent measurement of the coloured, oxidized form of the product at the corresponding wavelength. A sampling rate of up to 160 h–1 was attained. Relative standard deviations for the standard samples were usually less than 0.5%. The method was applied to the determination of phenothiazines in proprietary drugs and the results were comparable to those obtained by the official methods in the British Pharmacopoeia.

Article information

Article type
Paper

Analyst, 1991,116, 177-181

Flow injection method for the assay of phenothiazine neuroleptics in pharmaceutical preparations using ammonium metavanadate

S. M. Sultan, Analyst, 1991, 116, 177 DOI: 10.1039/AN9911600177

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements