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Issue 2, 1990
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Asymmetric synthesis of alpha substituted benzyl alcohols via the stereoselective addition of nucleophiles to homochiral tricarbonyl(η6-o-trialkylsilylbenzaldehyde)chromium(0) complexes

Abstract

The addition of nucleophiles to tricarbonyl(η6-o-trialkylsilylbenzaldehyde)chromium(0) complexes proceeds with complementary diastereoselectivities in the presence or absence of strong Lewis acids. The ready availability of homochiral aldehyde complexes, via classical resolution with L-valinol, permits the synthesis of alpha substituted benzyl alcohols with high enantiomeric excesses.

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Article type: Paper
DOI: 10.1039/P19900000393
Citation: J. Chem. Soc., Perkin Trans. 1, 1990,0, 393-407
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    Asymmetric synthesis of alpha substituted benzyl alcohols via the stereoselective addition of nucleophiles to homochiral tricarbonyl(η6-o-trialkylsilylbenzaldehyde)chromium(0) complexes

    S. G. Davies and C. L. Goodfellow, J. Chem. Soc., Perkin Trans. 1, 1990, 0, 393
    DOI: 10.1039/P19900000393

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