Chiral organometallic NADH mimics: stereoselective reduction of ethyl benzoylformate utilising the homochiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] at C-3 and a chiral β-hydroxy-carboxamide derived from valinol at C-5
Abstract
Homochiral complexes incorporating the chiral auxiliary [(η5-C5H5)Fe(CO)(PPh3)] at C-3 and a chiral β-hydroxy-carboxamide, derived from valinol, at C-5 reduce ethyl benzoylformate to ethyl mandelate in greater than 97% enantiomeric excess.