SCHEDULED MAINTENANCE
Oxophosphonoacetate (1), a novel biophosphate analogue containing a highly reactve α-ketone function at pH <7, proved inaccessible by direct hydrolysis of its previously unsynthesised triethyl ester (2), but can be made by oxygen transfer to the α-carbene of ethyl P,P-bis(trimethylsilyl) phosphonoacetate followed by heating in H2O.
C. E. McKenna and J. N. Levy, J. Chem. Soc., Chem. Commun., 1989, 246 DOI: 10.1039/C39890000246
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