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Issue 21, 1981
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Oxidative cleavage of peptide and protein disulphide bonds by gold(III): a mechanism for gold toxicity

Abstract

The oxidative cleavage of disulphide bonds to form the sulphonic acid derivatives is shown to be an important reaction of AuX4(X = Cl, Br) with proteins and peptides; the implications of this reaction for the toxicity of gold compounds are discussed.

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Article type: Paper
DOI: 10.1039/C39810001111
Citation: J. Chem. Soc., Chem. Commun., 1981,0, 1111-1114
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    Oxidative cleavage of peptide and protein disulphide bonds by gold(III): a mechanism for gold toxicity

    P. L. Witkiewicz and C. F. Shaw, J. Chem. Soc., Chem. Commun., 1981, 0, 1111
    DOI: 10.1039/C39810001111

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