The important antimalarial drug cycloguanil shares the following features with other antifolate agents studied crystallographically: (i) protonation at N(3), and (ii) a phenyl ring nearly perpendicular to the heterocycle.
C. H. Schwalbe and W. E. Hunt, J. Chem. Soc., Chem. Commun., 1978, 188 DOI: 10.1039/C39780000188
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