Kinetic study of the decarboxylation of 5-amino-1,3,4-oxadiazole-2-carboxylic acid to 2-amino-1,3,4-oxadiazole in water as a function of proton activity

Abstract

The rate constants of the decarboxylation reaction of 5-amino-1,3,4-oxadiazole-2-carboxylic acid (I) have been measured in water, over a wide range of proton activities (from H₀–0.95 to pH 4.77), at various temperatures, and the activation parameters have been determined. We present evidence for the occurrence of a decarboxyprotonation mechanism.