4,7-Dichloroquinoline undergoes ring scission on reaction with thiophosgene and barium carbonate. The resulting β-chloroisothiocyanatocinnamaldehyde [(6) or (7)] reacts with a wide variety of nucleophiles to give 2-substituted 4-formylmethylene-4H-3,1-benzothiazines. Some reactions of the 2-morpholinobenzothiazine (13) are described.
R. Hull, P. J. van den Broek and M. L. Swain, J. Chem. Soc., Perkin Trans. 1, 1975, 922 DOI: 10.1039/P19750000922
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