A number of 1-aryl-, 1,5-diaryl-, and 1-aryl-5-alkyl-biguanides bearing fluoro- and trifluoromethyl substituents on the aromatic ring have been synthesised; their chemical properties are described. Electron impact fragmentation in various 1-arylbiguanides has been investigated. Several of the compounds reported show anti-inflammatory, anorexigenic, and antimicrobial activities.
N. P. Buu-Hoï, P. Jacquignon, M. Mangane, S. Béranger and H. Pinhas, J. Chem. Soc., Perkin Trans. 1, 1972, 278 DOI: 10.1039/P19720000278
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