Euan A. F.
Fordyce
*a,
S.
Fraser Hunt
a,
Damien
Crepin
a,
Stuart T.
Onions
a,
Guillaume F.
Parra
a,
Chris J.
Sleigh
a,
John
King-Underwood
b,
Harry
Finch
c and
John
Murray
*c
aSygnature Discovery Ltd., BioCity, Nottingham, NG1 1GF, UK. E-mail: e.fordyce@sygnaturediscovery.com; Tel: +44 (0)1159415401
bCompChem Resource, Old Cottage Hospital, Homend, Ledbury, Herefordshire, HR8 1ED, UK
cPulmocide Ltd., 52 Princes Gate, Exhibition Road, South Kensington, London, SW7 2PG, UK. E-mail: john@pulmocide.com; Tel: +44 (0)2037639484
First published on 26th March 2018
Correction for ‘Conformationally restricted benzothienoazepine respiratory syncytial virus inhibitors: their synthesis, structural analysis and biological activities’ by Euan A. F. Fordyce et al., Med. Chem. Commun., 2018, DOI: 10.1039/c8md00033f.
17. The major impurity present in the mixture (29% isolated yield) was the corresponding propenyl thiophene 24, present as a 4:1 mixture of trans:cis isomers, which presumably form via elimination of triphenylphosphine oxide from the intermediate alkyloxytriphenylphosphonium species.
In addition, the wording in the Acknowledgements should be amended as follows:
The authors would like to thank Dr Kaz Ito (Pulmocide Ltd.) and Heather Allen (Pulmocide Ltd.) for the provision of the biological screening data for compounds 8a, 14 and 20.
The Royal Society of Chemistry apologises for these errors and any consequent inconvenience to authors and readers.
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