Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging

Yayun Wu; Zhizhen Chen; Pengfei Zhang; Lihua Zhou; Tao Jiang; Huajie Chen; Ping Gong; Dimiter S. Dimitrov; Lintao Cai; Qi Zhao

doi:10.1039/C8CC03037E

Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging†

Yayun Wu,‡^ab Zhizhen Chen,‡^c Pengfei Zhang,

*^ad Lihua Zhou,^a Tao Jiang,^a Huajie Chen,

^e Ping Gong,^a Dimiter S. Dimitrov,^f Lintao Cai

*^a and Qi Zhao

*^c

Author affiliations

* Corresponding authors

^a Guangdong Key Laboratory of Nanomedicine, Shenzhen Engineering Laboratory of Nanomedicine and Nanoformulations, CAS Key Laboratory of Health Informatics, Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, P. R. China
E-mail: lt.cai@siat.ac.cn

^b Key Laboratory of Molecular Nanostructure and Nanotechnology, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China

^c Faculty of Health Sciences, University of Macau, Taipa, Macau, China
E-mail: qizhao@umac.mo

^d Department of Chemical and Biological Engineering, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China
E-mail: pzhangad@connect.ust.hk

^e Key Laboratory of Advanced Functional Polymeric Materials of College of Hunan Province, and Key Laboratory of Environmentally Friendly Chemistry and Applications of Ministry of Education, College of Chemistry, Xiangtan University, Xiangtan 411105, P. R. China

^f Center for Antibody Therapeutics, University of Pittsburgh Medical School, PA, USA

Abstract

We developed highly bright and stable far-red emissive AIEdots by using a new kind of click-functional PEG grafted amphiphilic polymer to coat hydrophobic AIE-active polymers (PDFDP). Furthermore, an anti-HER2 recombinant fully human antibody was produced and conjugated on the AIEdots via metal-free click chemistry to fabricate in vivo tumor-targeting nanoprobes.

Chemical Communications

Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging†

Abstract

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Recombinant-fully-human-antibody decorated highly-stable far-red AIEdots for in vivo HER-2 receptor-targeted imaging

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