Issue 16, 2018

[Yb(AAZTA)(H2O)]: an unconventional ParaCEST MRI probe

Abstract

An unexpectedly slow exchange rate has been observed for the coordinated water molecule of [Yb(AAZTA)(H2O)] using 1H-NMR and CEST-MRI studies. This made it possible for the first time to exploit the bound water molecule of a LnIII complex with carboxylic donor groups for CEST imaging. This result envisages the development of a new family of thermodynamically stable ParaCEST probes based on anionic chelates.

Graphical abstract: [Yb(AAZTA)(H2O)]−: an unconventional ParaCEST MRI probe

Supplementary files

Article information

Article type
Communication
Submitted
09 Jan 2018
Accepted
30 Jan 2018
First published
30 Jan 2018

Chem. Commun., 2018,54, 2004-2007

[Yb(AAZTA)(H2O)]: an unconventional ParaCEST MRI probe

D. Delli Castelli, L. Tei, F. Carniato, S. Aime and M. Botta, Chem. Commun., 2018, 54, 2004 DOI: 10.1039/C8CC00193F

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