Issue 3, 2018

Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy

Abstract

Herein, the photosensitizer indocyanine green (ICG) is used to induce the self-assembly of antigens to form nanovaccines. Under near-infrared (NIR) laser irradiation, reactive oxygen species can be generated by nanovaccines to disrupt the membranes of endo/lysosomes, which helps to release antigens into the cytosol efficiently, thereby enhancing antigen cross-presentation and anti-cancer immunity. To the best of our knowledge, this study represents the first example of ICG as a biocompatible adjuvant to improve cancer vaccine efficacy.

Graphical abstract: Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy

Supplementary files

Article information

Article type
Communication
Submitted
22 Nov 2017
Accepted
30 Jan 2018
First published
02 Feb 2018

Biomater. Sci., 2018,6, 473-477

Photosensitizer-induced self-assembly of antigens as nanovaccines for cancer immunotherapy

F. Q. Cao, M. M. Yan, Y. J. Liu, L. X. Liu, L. Lu, H. Wang, Ch. Zhang, H. F. Sun, D. L. Kong and G. L. Ma, Biomater. Sci., 2018, 6, 473 DOI: 10.1039/C7BM01082F

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